Modelling the cellular interactions within the lining of the synovial joint

Synovial inflammation is now seen as an important part of the progression of joint diseases such as osteoarthritis. The synovial lining is a tissue with a mixed cell population, chiefly fibroblast-like synoviocytes which perform a key role in secreting synovial fluid and macrophages which act regulate inflammatory factors in the joint. There is emerging evidence of considerable cross talk between these two cell types with implications for the control of the expression of genes with a known link to osteoarthritis progression.

This project will make use of novel multi cellular tissue culture models to determine the paracrine processes that allow fibroblasts and macrophages to communicate within the synovium and the signalling pathways that are important in transducing these signals into cell function.

Training will be provided in a range of tissue culture and molecular biology techniques as well as providing an opportunity to perform cutting edge research into cell signalling in a system that models a key therapuetic target for chronic joint disease.

The Institute of Ageing and Chronic Disease is fully committed to promoting gender equality in all activities. We offer a supportive working environment with flexible family support for all our staff and students and applications for part-time study are encouraged. The Institute holds a silver Athena SWAN award in recognition of on-going commitment to ensuring that the Athena SWAN principles are embedded in its activities and strategic initiatives.

Candidates should hold or be expected to obtain a First or Upper Second class Honours degree or a Master’s degree in a relevant Biological subject. If English is not your first language you must have IELTS 6.5 or equivalent, with no component below 5.5.

How to apply: send initial enquiries to Simon Tew ([Email Address Removed])