Probing mechanisms of delivery of pharmaceuticals from nano-confined environments (KHIMYAKU17SF) at University of East Anglia on FindAPhD.com

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Prof Y Khimyak No more applications being accepted Self-Funded PhD Students Only

About the Project

Molecular level control of self-assembly of pharmaceuticals at different length scales is a significant challenge both in industrial and academic research. Confinement of pharmaceuticals in porous matrices can lead to stabilisation of unusual forms which can be beneficial for their delivery and improved bioavailability. Although such advantages have been illustrated on some examples, an in-depth molecular level of organisation and intermolecular interactions in such systems is needed to extend such approaches to new classes of pharmaceuticals with often reduced solubility or complex polymorphic behaviour. This project will aim to build correlations between the strength of intermolecular and host-guest interactions at different levels and dissolution profiles of nano-confined pharmaceutical materials. Probing such systems at various lengths scales (using NMR spectroscopy and other methods) will enable us to generate a formulation strategy towards novel nanoporous drug delivery systems with significantly improved level of control over their dissolution kinetics.

The PhD project is an excellent opportunity for a candidate to increase their expertise in a highly challenging area of research with considerable industrial relevance and potential to make a significant impact on the development of novel pharmaceutical materials. Through completing the project you will acquire knowledge of a wide range of computational and experimental methods (including different aspects of NMR spectroscopy) essential in highly competitive academic or industrial environments.

The project is available for graduates in the fields of chemistry, materials science, physics or pharmacy with a degree classification of 2.1 or above (of its equivalent). Informal enquiries should be made to Prof. Yaroslav Khimyak ([Email Address Removed]) as soon as possible.

The project may be available at an earlier start date of 1 April or 1 July 2017 but should be discussed with the primary supervisor in the first instance.

Funding Notes

This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees.

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.

References

i) Khimyak et al., Phys Chem Chem Phys, 2015, 24761.

ii) Fabian et al.. Mol Pharm, 2015, 2891.

iii) K. P. Nartowski, Y. Z. Khimyak et al Angew. Chemie Int. Ed., 2016, 55, 8904.

Where will I study?

University of East Anglia

We’re one of the UK’s leading research institutions, ranked 10th in the UK for the quality of our research outputs and with more than 1,500 research students.

Probing mechanisms of delivery of pharmaceuticals from nano-confined environments (KHIMYAKU17SF)

University of East Anglia School of Pharmacy