New aptamer selection strategies for custom biosensors

This project aims to develop new methods for selecting aptamers to be used in custom biosensors, for example narcotics detection. Aptamers are short DNA sequences that act like artificial antibodies. These selective recognition elements can be immobilized on electrode or nanoparticle surfaces to create highly sensitive and selective biosensor devices, for example colorimetric or electrochemical sensors. This project aims to innovate new ways of evolving aptamer sequences that will be optimised to function in these sensor devices.

The project will exploit the SELEX method for aptamer generation, and then develop new ways of evolving aptamer sequences based on surface chemistry effects. The project will use both established and new assays relating to oligonucleotide chemistry, surface chemistry, and electroanalytical chemistry, using facilities available at Victoria University of Wellington (VUW).

The successful candidate will join the aptasensor development group [1] at VUW [2], in collaboration with the Institute of Environmental Science and Research (ESR) [3]. The project will connect with start-up company AuramerBio Ltd [4], as well as the nationwide Centre of Research Excellence, the MacDiarmid Institute of Advanced Materials and Nanotechnology [5]. The university is located in Wellington, the thriving capital city of New Zealand [6].

We are seeking a highly motivated person with an excellent academic record and a good understanding of molecular biology or (bio)analytical chemistry. Applicants should have a biology or chemistry degree equivalent to the 4-year BSc (Honours) degree in New Zealand, with 1st class Honours, or an MSc or postgraduate Diploma. Candidates should satisfy the requirements for admission as a PhD candidate at Victoria University of Wellington [7].