Characterising cell type and tissue-specific functions of new centrosome components

All living things are composed of cells that multiply through cell divisions. For cells to maintain their genome stability DNA replication must be followed by correct transmission of replicated chromosomes into daughter cells. The success of chromosomes segregation depends on a robust mitotic spindle, a bipolar structure built of protein filaments called microtubules. A key microtubule nucleating and organising structure is the centrosome, a small non-membranous organelle. Besides cell division, the centrosome has also been implicated in migration, secretion, polarity and most importantly the formation of the primary cilium, a sensory and signalling organelle.
The Gergely group studies how cytoskeletal abnormalities lead to human diseases with a special focus on centrosomes and the microtubule cytoskeleton. Mutations in centrosomal genes have been linked to congenital developmental disorders like microcephaly and dwarfism. Cancer cells exhibit a range of centrosome abnormalities from structural to numerical aberrancies, but how and why these arise are not well understood. The primary interest of our laboratory is to elucidate the link between centrosome dysfunction and disease. This PhD project will contribute to this overall goal by elucidating the role of new centrosome components using genetic, molecular and cell biology tools in cell and animal models.

For up to date information about the research group, including their most recent publications, please see their website at:
http://www.cruk.cam.ac.uk/research-groups/gergely-group

Applicants should have excellent communication and team working skills with a degree in the biological or biomedical sciences. A Masters degree is not essential but some laboratory experience would be beneficial.

To apply, please send your academic CV and a covering letter as attachments to [Email Address Removed]
Your CV should include a list of the examinations taken at undergraduate level and if possible, your examination results. Also the names and contact details of two academic referees who have agreed to act on your behalf.
Your covering letter should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.