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  Innate lymphoid cells in cancer development


   Cancer Research UK Cambridge Institute

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  Dr T Halim  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

The immune system plays a critical role in many different aspects of cancer. Some immune cells are efficient at detecting and killing tumour cells, while in other instances inflammation is the underlying cause of cancer. The Halim lab is focused on a newly discovered group of immune cells, called innate lymphoid cells (ILC). Importantly, they have discovered that ILC have potent immune-regulatory properties that are likely to be critical in tumourigenesis.

This project aims to delineate the fundamental mechanism that regulate “good” versus “bad” inflammation in cancer. This understanding is critical for both treatment and prevention. This aim will be achieved through cutting-edge immunology techniques and reagents, which span from in vitro tumour-killing assays to monitoring the effect of ILC on tumour development by in vivo live imaging. This work will pioneer a new area of cancer immunology research, and will ultimately provide important new drug targets in patients.

The research project will involve the use of animal models, culture and genetic manipulation of primary immune cells, live cell imaging approaches, RNA-sequencing, quantitative proteomics, flow cytometry as well as basic cell biology and biochemistry. The ideal candidate requires a background in immunology, and would already have experience in one or more of the previously mentioned areas and would be highly motivated to drive an independent research project. Previous experience with mouse models is an advantage.

To apply, please send your academic CV and a covering letter as attachments to [Email Address Removed]
Your CV should include a list of the examinations taken at undergraduate level and if possible, your examination results. Also the names and contact details of two academic referees who have agreed to act on your behalf.
Your covering letter should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Funding Notes

This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.
No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.