Prof C Futter, Prof P Luthert
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Age-related macular disease (AMD) is the cause of over half of the cases of visual impairment in the UK but early intervention in the disease before the onset of blinding complications is not currently possible. We are looking for highly motivated candidates with excellent scientific potential for two studentships at the UCL Institute of Ophthalmology aimed at increasing our understanding of early events leading to AMD, to identify novel avenues for therapeutic intervention.
Project 2 of 2 Title: Modelling the role of lysosome dysfunction in the retinal pigment epithelium in the development of early age-related macular disease
Supervised by Professor Clare Futter this project aims to develop an in vitro model to study the role of lysosome dysfunction in early AMD. The project will test the hypothesis that compromised processing of lipids and proteins by the retinal pigment epithelium (the layer of supporting cells behind the light-sensing rods and cones) leads to lysosome dysfunction and ultimately to debris accumulation at the back of the eye. A combination of primary and stem cell-derived cell culture, light and electron microscopy, and biochemical analysis will be used to analyse lysosome activity and follow trafficking of proteins and lipids in RPE cell models where lysosomal function is compromised. Applicants should hold (or expect to obtain) a minimum upper-second degree or equivalent in an associated subject such as biological sciences. Previous laboratory-based research experience is desirable.
Link to project 1 of 2: https://www.findaphd.com/search/ProjectDetails.aspx?PJID=77921
The UCL Institute of Ophthalmology carries out research in well-equipped laboratories adjacent to Moorfields Eye Hospital NHS Trust. The Institute performs highly in Research Assessment Exercises and Research Excellence Framework, now as part of Clinical Medicine at UCL, demonstrating sustained excellence across a wide range of activities from basic sciences to clinically-related translational study. This is an ideal environment for research training.
The PhD student will benefit from state-of-art facilities within the UCL Institute of Ophthalmology and UCL School of Life and Medical Sciences. This project would benefit students wishing to establish a career in Biomedical Science.
Funding Notes
Applications are invited for this PhD studentship commencing as soon as possible. The studentship covers a tax-free stipend (£19,000 rising by £500 each year) in addition to covering tuition fees at the UK/EU rate.
Formal applications should be submitted in the form of a CV and covering letter outlining motivation, interest, and suitability for these projects should be sent to Prof Luthert at [Email Address Removed] or Prof Futter at [Email Address Removed]. Contact details for three references should also be provided. Informal enquiries may be made to Profs Luthert or Futter prior to submission.
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