Using functional and computational genomics to understand the link between genomic alterations, hypoxia and metabolism in cancer

Altered metabolism is a known hallmark of cancer, allowing cancer cells to survive and proliferate in a hostile microenvironment. Although some of the mechanisms have been described, translation of this knowledge into effective therapies and combinations strategies is still lacking. Integrating advanced computational and high-throughput screening techniques, this project aims to identify and characterise the genomic aberrations linked with the rewiring of metabolism pathways in cancer. This will enable us to understand the advantage that such rewiring offers in a hypoxic tumour microenvironment, and identify new possibilities for treatment and combination with radiotherapy.