Dr M D Santos-Nunes, Dr S Arif
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
Faculty of Health and Life Sciences
Department of Biological and Medical Sciences
This is a competitive 3 year Full Time PhD project
Research title - Early Evolution of Gene Duplicates - the effect of gene dosage on the fate of new gene duplicates
Supervisors Dr Maria Daniela Santos-Nunes and Dr Saad Arif
Eligibility: Home UK/EU applicants only ---- (who must be permanently resident in UK/EU)
Closing date: 16th December 2016 (12 midnight UK time)
Start Date: 18th September 2017
Value p.a.: Bursary of £14296 for Academic Year 2017/18 & fees
Requirements:
Applicants should be of the highest quality and capable of submitting a PhD thesis within 3 years. Applicants should have a first class or upper second class (minimum 2.1) honours degree from a Higher Education Institution in the UK or an acceptable equivalent qualification.
EU Applicants additional requirement for English language
A valid IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since 23rd April 2015 by an approved test centre.
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/491093/2016-01-11_-Approved_Secure_English_Language_Tests_and_Test_Centres_-_Website.pdf
Exceptionally we are prepared to consider alternative acceptable evidence of English Language ability.
Description of project:
Gene duplication is a major evolutionary mechanism leading to novel gene function and phenotypic diversity. However, very little is known about the period shortly after the duplication event. Molecular evolution studies suggest that gene dosage is an important contributory factor in determining whether new duplicates become fixed or not. However, in metazoans this evidence is largely based on statistical inference based on extant population data.
In this project, we aim to test the effect of gene dosage on the fate of new gene duplicates in an experimental framework using Drosophila melanogaster.
The research project student will generate tandem gene duplications, deletions and non-functional mutants using the CRISPR/Cas9 system and other transgenic tools to target both genes likely to result in genes with dosage-sensitive functions as well as genes that are expected to display less sensitivity to dosage. The effect of the newly generated transgenic alleles will be measured by conducting fitness assays and functional genomics to quantify transcription (qPCR, RNAseq) and enhancer interactions (4C-seq).
Contact details for informal enquiries:
Dr. Saad Arif e-mail address [Email Address Removed]
Dr. Maria Daniela Santos Nunes e-mail address [Email Address Removed]
How to apply
Download application from
http://www.hls.brookes.ac.uk/images/research/phd-studentship-application-form-jan-14.doc
With application enclose a CV and scanned copy of your degree certificates and transcripts plus two signed academic references. Additionally if appropriate an IELTS Academic test certificate from an approved test centre.
Applications only accepted by e-mail [Email Address Removed]
PLEASE NOTE THAT YOU MUST NOT SUBMIT ANY APPLICATION,CV or QUERIES VIA FINDAPHD
Funding Notes
Eligibility: Home UK/EU applicants only ---- (who must be permanently resident in UK/EU)
Closing date: 16th December 2016
Start Date: 18th September 2017
Value p.a.: Bursary of £14296 for Academic Year 2017/18 & fees
Applicants should have first class or upper second class (minimum 2.1) honours degree from a Higher Education Institution in the UK or an acceptable equivalent qualification.
EU Applicants-English language
A valid IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since 23rd April 2015 by an approved test centre.
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