In all lifeforms DNA is transcribed to create RNA templates for protein synthesis. This is known as the central dogma of molecular biology. Transcription is stimulated by regions of DNA called promoters. It has long been assumed that promoters drive transcription in one direction only. It seems illogical that promoters might simultaneously drive transcription “in reverse”. However, this phenomenon was reported for mammalian cells in 2008. Using genome-scale approaches, these studies concluded that mammalian promoters are inherently bi-directional; antisense and mRNA typically originate from the same region of DNA. This remarkable observation was met with some scepticism and any role remains a puzzle. In the intervening years, it has been assumed that the same does not happen in prokaryotic cells. However, in our recent work we have shown that bi-directional promoters are common in all prokaryotes (1). In this project, you will work on understanding what the role of bi-directional promoters is, how they work, and how they are regulated. Your findings are expected to have important implications for all prokaryotic organisms.
For more information about Professor Grainger’s lab and research please visit: http://graingerlab.com/
You are also advised to contact Professor Grainger directly to discuss your application prior to submission.
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To find out more about studying for a PhD at the University of Birmingham, including full details of the research undertaken in each school, the funding opportunities for each subject, and guidance on making your application, you can now order your copy of the new Doctoral Research Prospectus, at: www.birmingham.ac.uk/students/drp.aspx
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This project can be funded by the BBSRC via the Midlands Integrative Biosciences Training Partnership (MIBTP, available to all students) or by the Darwin Trust of Edinburgh (specifically to support overseas students). Deadlines: Jan 4th 2024 (for MIBTP) and Jan 7th 2024 (for Darwin Trust).
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