Computational modeling of type I collagen synthesis: development of an in silico system to investigate age-related tissue degeneration and fibrosis. at University of Liverpool on FindAPhD.com

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Dr EG Laird No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

The aim of this project is to develop a computational model to predict molecular components that regulate the synthesis of type I collagen, the most abundant protein in all vertebrates. Type I collagen synthesis becomes dysregulated with age with both over- and under-production causing numerous problems due to tissue and organ stiffening and fragility. Synthesis of type I collagen is highly regulated at the mRNA and protein levels and this project will focus on a post-transcriptional/co-translational control system that is hypothesized to malfunction to produce abnormal type I collagen during ageing. Alongside computational modelling you will learn key laboratory-based experimental techniques to measure mRNA and protein synthesis and will generate data to obtain important kinetic parameters. As such this is a multi-disciplinary project and provides an opportunity to develop skills that will be vital for future Biosciences research. Candidates with either a computational and/or biological background are welcome to apply as full interdisciplinary training will be provided. PhD supervisors have expertise in the regulation of collagen synthesis as well as computational modelling.

For further information see the website: https://www.liverpool.ac.uk/ageing-and-chronic-disease/

To apply:
Please submit a full CV and covering letter directly to [Email Address Removed]

Funding Notes

This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,296 for 2016-17). The PhD will start in October 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.

References

Mueller, A. J., S. Tew, O. Vasieva, P. D. Clegg and E. G. Canty-Laird (2016). "A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes." Scientific reports: In press.

Where will I study?

University of Liverpool

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Computational modeling of type I collagen synthesis: development of an in silico system to investigate age-related tissue degeneration and fibrosis.

University of Liverpool Institute of Ageing and Chronic Disease