Dr M Papamichos-Chronakis
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
This project will investigate the role of epigenetic control in regulation of the autophagic proteolytic response in budding yeast and human cells. Autophagy is essential for survival, differentiation, development and cellular homeostasis. Autophagy is strongly associated with aging and studies have suggested it plays a protective role from age-related diseases. Recent studies have highlighted a critical, yet largely uncharacterized, role for epigenetic control of autophagy by chromatin. Employing a combination of unbiased systems biology and molecular approaches this project will approach this fundamental question in order to reveal the physical and functional interface between chromatin control and autophagy response and elucidate the molecular underpinnings of this novel homeostasis pathway.
For further information see the website: http://www.ncl.ac.uk/camb/
To apply:
Please submit a full CV and covering letter directly to [Email Address Removed]
Funding Notes
This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,296 for 2016-17). The PhD will start in October 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
References
Lafon A*., Taranum S*., Pietrocola F., Dingli F., Damarys., Brahma S., Bartholomew B., and Papamichos-Chronakis M (2015). INO80 remodeler facilitates release of RNA Polymerase II from chromatin for ubiquitin-proteasomal degradation. Molecular Cell 60: 784–796. *equal contribution. PMID: 26656161.
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