Programmed necrosis in skin and joint inflammation

A fully funded PhD position is available from April 2017 at Division of Infection and Immunity, Cardiff University School of Medicine, under supervision of Dr. Bonnet.

The ground-breaking discovery of molecular regulation of necrosis is opening new perspectives in inflammation biology. I have previously shown that the RIPK3-dependent necroptotic cell death of keratinocytes triggers skin inflammation in vivo. Recently, I unravelled an unexpected role for molecules called alarmins in the regulation of necroptosis in human skin inflammation.

The project aims at delineating the role of alarmins in necroptosis-induced inflammation to develop innovative therapeutic strategies. We will decipher the alarmins-activated molecular pathways, using in vivo models, histology, molecular and cellular biology. Expertise in confocal microscopy, cell death, protein analysis and in vivo models would be strongly appreciated.