Investigating endocrine regulation of human T cell immunity and immunosenescence

Applicants are invited for a 3 year, fully funded PhD Studentship in the new Immunology Section, School of Biosciences and Medicine, University of Surrey, Guildford. This PhD position starts in October 2017 and is based primarily in the laboratory of Dr Natalie Riddell. Dr Riddell has substantial research experience in endocrine regulation of T cell function and ageing of the immune system. The successful applicant will be co-supervised by the Head of Immunology, also an expert on ageing and the immune system, Prof Deborah Dunn-Walters.

Project description

Background
Every-day physiological and psychological stressors can greatly affect T cell immunity, and therefore our health in general. The two main mediators of this stress response are the hormones adrenaline and cortisol, which are both important regulators of the immune system. Within the T cell compartment these hormones modulate almost every aspect of CD4 and CD8 T cell immunity, including the anatomical distribution of cells, the polarization of cell differentiation, and cell functions such as, cytokine production, proliferation, cytotoxicity, and suppressor activity. Disruptions of normal circadian rhythmicity of adrenaline and cortisol secretion, as is seen in shift workers and during psychological stress, can thus have profound effects on T cell immunity and this is particularly true in elderly individuals. Furthermore, prolonged stress has been found to cause premature and accelerated ageing of the immune system. Altered endocrine regulation of immune function may therefore be a contributing factor to the reduced immune protection and increased infection that is observed in the elderly population. Identifying the cellular mechanism involved in endocrine regulation of T cell immunity may lead to novel interventions to prevent or reverse the loss of immune function commonly found in older individuals.

Objectives
The aim of the studentship is to investigate the mechanisms governing endocrine regulation of human T cell immunity and whether cortisol and adrenaline may play a role in the development or maintenance of senescence in aged T cells.

Experimental Techniques used
This project offers world-class training and access to cellular and molecular techniques including flow cytometry (multi-parameter extracellular, intracellular and phospho), tissue culture, in-vitro pharmacological manipulations, cell activation and differentiation methods, chemotaxis assays, metabolic analysis (Seahorse), western blotting, and qRT-PCR. In addition, human in-vivo psychological or environmental manipulations techniques may be used.

Person Specification
This is an exciting opportunity for an enthusiastic individual to be part of a vibrant and supportive research community and receive extensive training for a career in Immunology and Cellular Biology.

Applicants should have:
1. At least an upper second class honours degree (2.1) or equivalent in (but not restricted to) Biological or Biochemical sciences from a UK university or equivalent standard from an EU based University. Applications are particularly welcome from applicants with a strong background in Immunology and/or Cellular Biology.
2. Fluency in English language
3. Motivation and enthusiasm for work and should be capable of thinking and working independently.
4. British or EU/EEA nationality.
5. Applicants with greater than 3-6 month’s practical laboratory experience will be at an advantage.

The University of Surrey values diversity and is committed to equality of opportunity.

Application and further details

Applicants should apply directly to [Email Address Removed] including a covering letter stating their research interest and experience/ capabilities, a CV, and at least two academic references.

Informal enquiries are welcome and should be directed to Dr Natalie Riddell; Email [Email Address Removed].