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  Identification of genomic lesions in NGS data of leukemic cells for clinical applications


   CEITEC

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  Dr V Bystrý, Prof S Pospíšilová  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Human lymphoproliferative disorders such as leukemias are known to be associated with a characteristic genomic alterations, such as chromosomal translocations typically affecting a limited number of recurrent genes with several variable partner genes. The presence of such fusion genes might be instrumental for the development of the disease and its recognition and identification an important prognostic marker. Even more importantly fusion genes can be targeted by chemotherapy and/or new drugs, therefore genomic profiling has the potential to identify new potentially druggable targets. The aim of the PhD study will be to work with NGS systems and to analyse the resulting data with the focus on detection and characterisation of genetic abnormalities associated with leukemia. Student should also design and implement an automated system for identification, storing and classification of the genomic aberrations.

All general enquiries should be directed to Olga Křížová ([Email Address Removed]). Scientific inquiries can be addressed to the supervisor ([Email Address Removed]).


Funding Notes

Admission for studies, student registration for the full-time study programme and proper fulfilment of student duties constitute the student’s right to a regular scholarship of 20 000 CZK (730 EUR). Information is available at http://ls-phd.ceitec.cz/information-for-students/#fund

Living costs and other practicalities available at http://ls-phd.ceitec.cz/practical-information-for-life-in-brno/

References

Applicants who wish to pursue a degree at the CEITEC PhD programme must hold the equivalent of a Master's degree (MSc) in the same or similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master's degree, however, the applicant should obtain the degree within five month after the application deadline.