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Investigation of virulence determinants and virulence regulons in Campylobacter spp.

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Campylobacter jejuni and C. coli are the most common aetiological agents of acute bacterial diarrhoeal disease in humans. Although a few putative virulence characteristics, namely toxin production, adherence and invasion have been described, the mechanisms by which Campylobacters cause disease remains poorly understood. The group was closely involved in the genome sequence project and is an integral part of the functional genomic analysis of C. jejuni.

Projects involve investigation of the role in Campylobacter pathogenicity of genes associated with lipo-oligosaccahride biosynthesis, stress responses and iron uptake systems using molecular genetic approaches and specific phenotypic assays. In addition, the regulatory mechanisms utilized by Campylobacter, including those involving members of the Two Component and Fur families of regulators, are being characterized by the construction of mutants, gene expression studies and DNA binding experiments. The projects contribute to understanding the mechanisms involved in host:bacterial interactions during Campylobacter infection and will help in the design of novel preventative measures.

We are an equal opportunities employer and particularly welcome applications for Ph.D. places from women, minority ethnic and other under-represented groups.

References

van Vliet et al. (2000) FEMS Microbiol. Lett. 188, 115-118.

Wood, A. C., et al (1999) Microbiology 145, 379-88.

van Vliet, A. H., et al (1999) J Bacteriol. 181, 6371-6.

Bras, A. M., et al (1999) J Bacteriol. 181, 3298-302.

Parkhill, J. et al (2000) Nature 403, 665-668.

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