Funded PhD project (European/UK students only)
Self-correcting mismatches during high-fidelity DNA replication. (2017) Fernandez-Leiro R, Conrad J, Yang JC, Freund SM, Scheres SH, Lamers MH. Nat Struct Mol Biol. 24, 140-143.
Fernandez-Leiro R, Conrad J, Scheres HWS and Lamers MH. (2015) Cryo-EM structures of the E. coli replicative DNA polymerase reveal dynamic interactions with clamp, exonuclease and τ. eLife 4:e11134
Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM and Lamers MH. (2015) Replication fidelity in M. tuberculosis is mediated by an ancestral prokaryotic proofreader. Nature Genetics 47, 677-681
Toste Rêgo A, Holding A, Kent H and Lamers MH. (2013) Architecture of the Pol III-clamp-exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair. EMBO J. 32, 1334-43