Dr B Jones, Dr J Minnion, Prof S R Bloom
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Applications are invited for a 3-year PhD studentship to work in the Section of Investigative Medicine within the Faculty of Medicine of Imperial College London, Hammersmith Campus. The project involves the investigation of incretin receptor pharmacology, biased agonism and drug discovery.
Project background and objective: Gut derived peptide hormones such as glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM) and glucose-dependent insulinotropic polypeptide (GIP) play a major role in postprandial physiology, appetite regulation, and energy homeostasis. Our group has studied the action of these hormones for many years (see Kreymann et al, Lancet, 1987, Turton et al, Nature, 1996, Tan et al, JCEM, 2014). We have now developed a library of over 4000 peptide analogues as part of a drug discovery programme for treatment of obesity and type 2 diabetes. You will exploit this unique resource to learn about the molecular basis of incretin receptor responses.
Project aims:
1. Identify agonist-related structural determinants of receptor activation
2. Identify downstream consequences of biased signalling in vitro and in vivo in relation to glucose and energy homeostasis
3. Assess therapeutic potential of novel compounds in diabetes and obesity
The successful applicant will be joining an internationally-renowned research group, within one of the world’s top research universities. The Division has an excellent publication record in top rated research journals and is well funded from a number of different sources. Full training will be given in all applicable techniques.
In order to be eligible for a Studentship, students must satisfy the usual eligibility criteria, including adequate academic qualifications and UK residence
The academic supervisors will be Professor Sir Stephen Bloom and co-supervisors Dr James Minnion and Dr Ben Jones.
Funding Notes
Applicants must have or expect to have obtained at least a 2:1 from an EU university in a relevant area such as pharmacology, biochemistry, physiology or similar. A Masters degree is preferable but not essential. Applicants must also meet Imperial College’s English language requirements – further details can be found at http://www3.imperial.ac.uk/registry/admissions/pgenglish.
Continue with Facebook
