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Conformational dynamics of SMC complexes at the molecular level

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  • Full or part time
    Prof Sobott
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Upon cell division, all organisms must ensure that each daughter cell contains a single copy of each chromosome. The SMC complex (condensin) plays an essential role in this process in all domains of life, but its mechanism of action is completely unknown. Popular models suggest that condensin assembles to form a large proteinaceous ring, the opening and closing of which may be controlled by ATP. This project aims to characterize the structural changes and dynamics of condensin in a model bacterial system. To do this, you will use cutting-edge biophysical techniques pioneered by the Sobott and Craggs labs, including Native Mass-Spectrometry and Ion Mobility and single-molecule FRET, and so gain novel insight into the mechanism of a DNA remodeling machine at both the molecular and cellular level. We are looking for a student from a physical sciences background, with a strong interest in applying their skills and knowledge to biology; or alternatively, a molecular biologist, eager to learn and apply quantitative approaches. This project presents a unique opportunity to learn and develop techniques to study the structure and dynamics of large, multi-protein-DNA complexes, which are not easily characterized by classical methods.

Funding Notes

To start in Oct 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject.

This project is eligible for BBSRC funding. We are advertising a range of projects and funding will be awarded to the best candidates. The funding covers fees at UK/EU level plus a stipend of £14,553 for 4 years. Please note that candidates must have been resident in the UK for the last 3 years to be eligible for full funding; candidates who have not been resident in the UK are eligible for a fees-only studentship.

Please apply online: https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon

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