Prof E Boke
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Keywords: Mitochondria, oocyte, dormancy, proteomics, imaging
We invite applications for 1 fully-funded PhD studentship to investigate mitochondrial activity in oocytes. We seek to discover mechanisms that protect mitochondria in oocytes from ageing.
Female germ cells, called oocytes, are highly specialised cells. They ensure the continuity of the species by providing the female genome and mitochondria, along with most of the nutrients and housekeeping machinery the early embryo needs after fertilisation. Oocytes are remarkable in their ability to survive for long periods of time, up to 50 years in humans, and retain the ability to give rise to a young organism. Surprisingly little is known about oocyte dormancy.
The goal of the PhD project is to combine genetic and biochemical perturbations with imaging and the state of the art proteomics techniques to reveal the mechanisms dormant oocytes employ to remain viable. More specifically, the PhD student will study the metabolic nature of mitochondria in early oocytes of mouse and Xenopus laevis frogs.
This project is especially well suited for students with a background in life sciences. Experience with techniques of proteomics, molecular biology, cloning, light and confocal microscopy, and quantitative image analysis would be desirable but not essential.
Applicants must have obtained a University Degree and a Masters Degree in biomedical sciences within the European Higher Education System (minimum 300 ECTS) or equivalent in a relevant life science disciplines.
Applicants should send a current CV, academic transcripts, a personal statement, and the names of 2+ referees to [Email Address Removed]
http://www.crg.eu/en/elvan-boke
Funding Notes
The selected PhD student will receive an annual work contract with a competitive salary that will be renewed annually for a maximum of 4 years following the applicable national regulations, including full health and occupational insurance coverage.