Determining the impact of neocortex size changes on information processing: Implications for neurodevelopmental disorders

Many neuropsychiatric disorders are associated with abnormal neurodevelopment. During neocortical development, the number of cortical neurons is determined by a balance between the proliferation and differentiation of neural progenitor cells. Perturbations of this crucial period can lead to micro- or macrocephaly, often resulting disorders including autism and schizophrenia. Recently it has been shown that phosphorylation of Axin plays a critical role in cortical neuron production (Fang et al., 2013) and prevention of Axin degradation by the small molecule XAV939 can induce the overproduction of a specific cell class in the neocortex (Fang et al., 2014). More importantly, the overproduction of superficial neocortical neurons causes autism-like behavioural phenotypes. However, we know little about how the overproduction of neocortical neurons leads to autism-like behaviours. In this project, combining multidisciplinary approaches (e.g., in vivo electrophysiological, optogenetic, and behavioural approaches) in this animal model, we will determine how the overproduction of a subset of neocortical neurons affects neocortical information processing at the neural circuit level. This project will provide further insights into the importance of the optimal number of neurons for brain functions as well as the mechanisms underpinning neuropsychiatric disorders, including autism.

The successful candidate should have or expect to have an Honours Degree at 2.1 or above (or equivalent) in Neuroscience, Bioengineering or related fields, and should also wish to learn advanced neurobiological skills.

In the first instance, candidates may send their application to Dr Shuzo Sakata ([Email Address Removed]), including a CV and cover letter, detailing their motivation for this particular PhD project.