Prof G Battaglia
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
The UCL Centre for Doctoral Training in Molecular Modelling and Materials Science is offering a fully funded studentship to a highly motivated candidate to start in September 2017. The project will be in collaboration with MedImmune. The student will carry out his/her doctoral research at UCL and also have the opportunity for work placements at MedImmune in their Cambridge facilities.
We will design complex (yet affordable) synthetic nanocarriers that will be equipped with multiple ligands. We will start mapping out the different components that will enable super-selective binding including ligand affinity, ligand tethering and ligand density. We will demonstrate that the combination of multiplexed low-affinity ligands on the surface of a nanocarrier results in binding limited to entropy-driven avidity, hence targeting cells that express all the corresponding receptors at high density. This results in a super-selective binding that enables the precision targeting of unique cell populations, with negligible levels of unspecific interactions. We will subsequently associate these with cellular internalisation and transcytosis to convert effective binding with cell entry.
The candidate will join an exciting team in a dynamic research environment at UCL associated with the Battaglia Research Group http://www.battagliaresearchgroup.org project working in collaboration with both a computational and experimental group at MedImmune.
Interested candidates should contact Prof Giuseppe Battaglia [Email Address Removed] with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged.
Applications will be considered until 20th July 2017 or as soon as a suitable candidate has been identified.
Funding Notes
Due to funding restrictions, this studentship is only open to applicants from the UK and EU, who have been resident in the UK for at least 3 years preceding their start on the programme or have indefinite leave to remain in the UK.
You should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in chemistry or related subject with some experience of nanoparticle preparation.
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