Pharmacological study of NADPH oxidases as targets for the development of novel antithrombotics.

Two NADPH oxidases (NOXs) are expressed in platelets: NOX1 and NOX2. Our preliminary data show that the activity of NOXs is necessary for full activation of platelets. The modulatory effect of NOXs on platelet responses was abolished upon genetic silencing of the Src Homology Phosphatase 2 (SHP2). This studentship will investigate the interplay between NOXs and SHP2 in the regulation of platelets and the potential of NOXs as targets for antithrombotic drug development. We aim to determine: 1) the role of NOX1 and NOX2 activity in platelet stimulation; 2) the molecular mechanisms linking platelet stimulation to NOX activation; 3) the exact function of NOXs in platelet signalling and the haemostatic responses; 4) the effect of NOX inhibition on haemostasis and thrombosis in vitro. This information will help us to better understand platelet regulation and determine whether NOXs are suitable antiplatelet drug targets.

The University of Exeter Medical School is seeking to attract self-funded PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally rated research. This studentship will be hosted by the laboratory of Dr Giordano Pula within the Institute of Biomedical and Clinical Science (IBCS). Current research in the laboratory of the supervisor focuses on redox-dependent regulation of blood clotting and cardiovascular disease 1-3 and is funded by the British Heart Foundation:

https://www.bhf.org.uk/research-projects/2016/11/18/08/34/characterisation-of-the-role-of-nadph-oxidase-1-in-collagendependent-activation-of-platelets-a-potential-target-for-the-development-of-novel-antithrombotics

In addition to critical research and transferrable skills, the student will be trained in phlebotomy, blood handling, blood cell isolation, cell biology and biochemistry of cellular communication, immunochemistry and cell imaging.

Academic Supervisors:
Dr Giordano Pula, Senior Lecturer in Cardiovascular Bio-medicine, Institute of Biomedical and Clinical Science, University of Exeter Medical School: http://medicine.exeter.ac.uk/people/profile/index.php?web_id=Giordano_Pula


Entry requirements:
Applicants should be highly motivated and have, or expect to obtain, either a first or upper-second class BSc (or equivalent) in a relevant discipline. International applicants must also have IELTS [International English Language Testing System] score of 7 and above (or equivalent qualification). For more information, please see our English Language Requirements: http://www.exeter.ac.uk/postgraduate/apply/english/

How to apply:
Please send a CV, Covering letter (outlining your academic interests, prior research experience and reasons for wishing to undertake the project) and copies of degree transcript (giving full details of subjects studied and grades/marks obtained (this should be an interim transcript if you are still studying) to UEMS Graduate Research: [Email Address Removed]

Candidates are encouraged to make an expression of interest, as early as possible. The award will be filled as soon as a suitable candidate can be found.

If you have any general enquiries about the application process please email [Email Address Removed] Project specific queries should be directed to Dr Pula.

We regret that only candidates shortlisted for interview will be contacted.