Non-invasive visualization of enzyme activity with hyperpolarized MRI – Developing novel translational molecular imaging biomarkers

Visualizing molecular processes with targeted techniques such as fluorescence labelling has revolutionized bioscience. Transferring this approach in vivo, however, remains a fundamental challenge. Magnetic resonance imaging (MRI) provides an unparalleled insight into the body with high spatial resolution and structural detail. But MRI lacks sensitivity and specificity to detect low concentration molecular targets. We have developed nanosized MRI sensors that allow us to monitor key molecular processes in vivo. Hyperpolarization can increase the MR signal by five orders of magnitude, dramatically lowering the detection limit of MRI to a target molecule. Hyperpolarization MRI is challenging, because the signal, while greatly enhanced, decays rapidly. With our partner in this PhD project, GE Global Research, the PhD project will focus on the development of novel MR methods for hyperpolarised imaging.

To discuss in more detail, please contact Dr Henryk Faas, [Email Address Removed].