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  Infection, Inflammation and metabolism in fibrotic lung disease


   National Heart and Lung Institute

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  Dr P Molyneaux  No more applications being accepted  Funded PhD Project (European/UK Students Only)

About the Project

3yr PhD funded through the NHLI Foundation - starting Autumn 2017

Applications are invited from candidates with a Master’s degree (or equivalent) in cellular, molecular or clinical immunology or a related discipline for a 3-year PhD studentship to investigate the pathogenesis of Idiopathic Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive disease of unknown etiology with a 5-year survival rate of only 20%. It affects over 32 000 individuals in the UK and current evidence suggests IPF develops in genetically susceptible individuals after repeated episodes of alveolar injury. This project will build upon work within the group to understand the interaction of lung-resident inflammatory cells, the airway epithelium, lung microbiome and metabolome in driving the development and progression of pulmonary fibrosis.

The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. In addition, the institute provides extensive collaborative opportunities with other research groups.
All students will belong to Imperial’s award winning Graduate School which provides a comprehensive Professional Skills Programme.

How to Apply

Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution, and must fulfil the College’s admissions criteria.

To apply please send a CV, a 400 word personal statement, and the names and addresses of at least two academic referees to Dr Phil Molyneaux on [Email Address Removed].

For informal enquiries regarding the PhD project, please contact Dr Phil Molyneaux ([Email Address Removed]).

Application deadline: Sunday 27th August midday

Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.



Funding Notes

The studentship has been made possible by the NHLI Foundation, and will be funded for 3 years with a tax free bursary of £18,000 per annum. Tuition fees at the Home/EU rate will also be paid.

The studentship will be based within the Inflammation Repair and Development (IRD) section and will be supervised by Dr Philip Molyneaux and Professor Clare Lloyd. The successful candidate will receive training in a wide variety of techniques including: In vitro cell culture, (stimulation and analysis); Flow cytometry, extracellular staining for phenotyping of cells and intracellular for cytokine analysis; Cell sorting using magnetic bead systems; ELISAs and multiplex assays for cytokines and chemokines; RNA extractions and qPCR; DNA extractions, qPCR, 16S sequencing and data analysis, migration assays; development of complex co-culture systems; imaging (confocal microscopy, intravital microscopy, imaging of precision cut lung slices).