Challenge and Limits of Genome Assembly under a Substitution Model

The modern genome assembly technology provides reads which can perfectly reconstruct the original Deoxyribonucleic acid (DNA) sequence. However, the quality of reconstructed sequence is influenced by reads length and coverage depth. There is an advantage to recover the sequence by using short length reads containing less error. However, a certain critical length is always needed to successfully complete the task of reconstruction. When reads length is below a threshold, reconstruction tends to be impossible. Long length reads seem to provide sufficient information for reconstruction at the expense of increased error, which may lead to higher probability of failure. The common errors in reads can be classified as several types such as substitution, deletion, substitution and erasure model. This project aims to overcome the error correction problems occurred in reads under the substitution model. This will enable researchers to prospect this area of research and make high impact contributions to the emerging field.
Degree:
The student will be awarded a Ph.D. degree from the University of Liverpool (UK) upon successful completion of the program.
For more information about doctoral scholarship and Ph.D. programme at Xi’an
Jiaotong-Liverpool University (XJTLU): Please visit
http://www.xjtlu.edu.cn/en/study-with-us/admissions/entry-requirements
http://www.xjtlu.edu.cn/en/study-with-us/admissions/scholarships
How to Apply:
Interested applicants are advised to email [Email Address Removed] (principal
supervisor’s email address) the following documents and copy
[Email Address Removed] (please put the project title in the subject line).
• CV
• Two reference letters with company/university letterhead
• Personal statement outlining your interest in the position
• Proof of English language proficiency (an IELTS score of above 6.5 or
equivalent is required
• Verified school transcripts in both Chinese and English (for international
students, only the English version is required)
• Verified certificates of education qualifications in both Chinese and English
(for international students, only the English version is required)
Informal enquiries may be addressed to Dr. Siyi Wang ([Email Address Removed]),
whose personal profile is linked below,
http://www.xjtlu.edu.cn/en/departments/academic-departments/electrical-andelectronic-
engineering/staff/siyi-wang
Contact
Please email [Email Address Removed] (principal supervisor’s email address) and copy [Email Address Removed] with a subject line of the Ph.D. project title
Requirements:
The candidate should have a first class or upper second class honours degree, or a master’s degree (or equivalent qualification), in electrical and electronic engineering, computer science and engineering, applied mathematics, physics, physical biology and other related areas. Evidence of good spoken and written English is essential. The candidate should have an IELTS score of 6.5 or above, or an equivalent qualification, if the first language is not English. This position is open to all qualified candidates irrespective of nationality.
Additional requirements specifically for this Ph.D. project can be found via this link.