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Study of synthesis and properties of cystamine modified oligonucleotides


Project Description

For the Marie Sklodowska Curie Action - Innovative Training Network (MSCA-ITN) DNA Repairman, we are looking for a chemist with experience in organic synthesis on the subject of designing chemical modified in chemical synthesis of nucleic acids. This researcher will be placed with FutureSynthesis sp. z o.o. in Poznań, Poland to work on an individual research project within a large European research network.

The presented project involves both basic and application research based on the cross-linking of biopolymers (nucleic acid and peptides) in molecular sciences. Cross-linking will be implemented by modiefied nucleic acids contained the disulfide linkers like cystamine which modify the polymers in the chemical interaction to create the future cross-link bonds.

You will be immersed in an international, multidisciplinary training environment in fundamental life sciences and obtain insight into the role of basic chemical and physical principles underlying molecular steps in complex yet integrated molecular processes. As the research relies on cutting-edge technologies, development of new approaches will be an integral part of your project. Because of the close collaboration between academia and industry, you will furthermore learn how technology development drives innovation in research and how basic research questions can drive innovative technology into marketplace developments.

DNA Repairman
DNA Repairman is a collaboration between Erasmus MC (Netherlands), the National Center for Scientific Research (France), FutureSynthesis sp.z o.o. (Poland), the Medical Research Council (UK), the Netherlands Cancer Institute (Netherlands), Justus-Liebig university (Germany), University of Bristol (UK) and Elvesys SAS (France) to provide 12 PhD students with unique and innovative interdisciplinary training in cutting-edge biophysical research methodologies to address central questions in biology with relevance for human health. The overall research aim of the project is to unravel the mechanistic details of the regulated assembly of molecular machines for DNA repair. Academic and industrial laboratories will develop new reagents, assays, technology and software to analyze fundamental chemical and physical principles underlying the molecular organization of two critical DNA repair pathways: DNA mismatch repair and transcription-coupled nucleotide excision repair.

We are looking for an enthusiastic candidate with a MSc in Biochemistry, Chemistry or closely related field, experience with organic synthesis, and good command of English (IELTS grade min. 6.5, or equivalent).

Terms of employment
You will receive a temporary position for 3 years. Employment terms for Marie Curie projects (http://ec.europa.eu/research/mariecurieactions/index_en.htm) apply.

Contact information
For more information on the DNA Repairman training network, see http://www.dnarepairman.eu. For more information about this position, please contact Prof.Dr. Marcin Chmielewski ().

Application
Applications can be sent to ms. Geerte Slappendel () stating vacancy code FS1 in the subject line. Applications should include a cover letter explaining why you are interested in the project, resume, and detailed academic transcripts. Application deadline is October 31st, 2017.

Funding Notes

There are strict eligibility requirements for the PhD positions in MSCA-ITN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.
• Applicants should not have resided or performed their main activity (work, studies, etc) in Poland for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.
• Applicants for the PhD positions should be in the first 4 years of their research careers and not have been awarded a doctorate. This 4 year period is measured from the date of obtaining your MSc degree.

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