Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening at Cardiff University on FindAPhD.com

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Dr S Dewitt No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

We have designed a method to produce tissue closely resembling articular cartilage from human stem cells.

Novel biophysical techniques will confirm similarities in matrix architecture and cellular differentiation, enabling its use in research on osteoarthritis development, identification of disease biomarkers and screening of therapeutic agents.

Osteoarthritis (OA) is a chronic, progressive joint disorder with 8 million sufferers in the UK alone. There is an urgent clinical need to:

better understand the mechanisms underlying disease development and progression
develop diagnostic assays for early identification and stratification of patients at risk of developing OA
streamline methods of drug screening.

Progress in all 3 areas requires realistic in vitro models.

For further information on this project, please see our website: https://www.cardiff.ac.uk/study/postgraduate/research/programmes/project/validation-of-a-stem-cell-derived-cartilage-model-for-osteoarthritis-research-and-drug-screening

Funding Notes

These research projects are in competition with 71 other studentship projects available across the GW4 BioMed MRC Doctoral Training Partnership. Up to 19 studentships will be awarded to the best applicants. Find out more information about the DTP including how to apply: https://www.cardiff.ac.uk/study/postgraduate/funding-and-fees/view/mrc-gw4-biomed-doctoral-training-partnership-phd-in-dentistry

Applicants who are classed as international/overseas for tuition fee purposes are not eligible for funding.

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Cardiff University

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Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening

Cardiff University Cardiff School of Dentistry