Dissecting the impact of L-selectin proteolysis on T lymphocyte dependent virus immunity
Killer T cells enter infected tissues to kill virus. T cell entry into infected tissues requires the homing molecule L-selectin. When killer T cells see virus they digest L-selectin and release fragments into the cell.
This project will determine how fragments of digested L-selectin control the ability of killer T cells to detect and kill virus.
Viral infection represents a severe economic burden. The ability to combat viral infections depends on a subset of white blood cells called T cells. During infection, virus-specific T cells are activated to “killer” status to clear virus. How killer T cells find infected tissues, such as influenza-infected lungs, is not known. We showed that a homing molecule called L-selectin, thought to be lost during T cell activation, is key to this process. When a T cell detects virus, L-selectin is digested from the cell surface and lost; but quickly replaced.
For further details of this project, please see our website: https://www.cardiff.ac.uk/study/postgraduate/research/programmes/project/dissecting-the-impact-of-l-selectin-proteolysis-on-t-lymphocyte-dependent-virus-immunity
These research projects are in competition with 71 other studentship projects available across the GW4 BioMed MRC Doctoral Training Partnership. Up to 19 studentships will be awarded to the best applicants. Find out more information about the DTP including how to apply: https://www.cardiff.ac.uk/study/postgraduate/funding-and-fees/view/mrc-gw4-biomed-doctoral-training-partnership-phd-in-medicine2
Applicants who are classed as international/overseas for tuition fee purposes are not eligible for funding.