Prof S McCormick
Applications accepted all year round
Competition Funded PhD Project (Students Worldwide)
About the Project
A PhD project is available for an international or NZ candidate to study lipoprotein genetics. Elevated levels of lipoprotein(a) [Lp(a)] are a major independent risk factor for premature cardiovascular disease (CVD). Lp(a) levels are hugely influenced by the LPA gene, however, the gene is largely uncharacterised due to its highly repeatitive nature. This project aims to use new sequencing technology to gain sequence data for the repeatitive region of LPA to identify SNPs in this region associated with either elevated (or low) Lp(a) levels in a local population.
In contrast, elevated levels of high density lipoproteins (HDL) are protective against developing CVD. The genetic basis for high HDL levels is not well understood, however, recent GWAS studies have identified 38 loci associated with HDL levels. This project aims to gain sequence data from these 38 loci in individuals with high HDL levels. Functional studies will be performed on gene variations of interest in the LPA and HDL-associated genes.
The project will be based at the Department of Biochemistry at the University of Otago, Dunedin, New Zealand (http://www.otago.ac.nz/biochemistry/index.html) supervised by Professor Sally McCormick. The successful candidate will be supported through the University of Otago Doctoral Scholarship scheme (http://www.otago.ac.nz/study/scholarships/database/otago014687.html ). This provides a NZ$25,000 tax-free stipend per annum, plus all tuition fees, for 3 years (regardless of the nationality of the candidate). Please note these scholarships are awarded based on student grades plus evidence of research excellence (for example publications). Applicants must have a strong BSc (Hons) or MSc degree in a relevant discipline, good communications skills as well as a willingness to learn, develop and apply new techniques. A background in genetics and biochemistry is essential. The start date is negotiable with students who are completing their degree this semester/term welcome to apply.
To apply, please contact Prof Sally McCormick ([Email Address Removed]) to explain your interest in this project and how this relates to your previous experience. Please include your CV, academic transcript, a copy of your research dissertation or thesis, the names of at least two academic referees and an English language test document if required (http://www.otago.ac.nz/international/postgraduate/).
Funding Notes
The successful candidate will be supported through the University of Otago Doctoral Scholarship scheme, with scholarships awarded based on student grades plus evidence of research excellence. International candidates receive the same package as New Zealand residents provided they reside in New Zealand for the duration of the project and study under a New Zealand student visa.