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  Developing bioinformatic methods for probing bacterial CRISPR-Cas regulation


   Bio-Protection Research Centre

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  Assoc Prof Paul Gardner  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

CRISPR-Cas systems may be regulated by RNA-binding proteins. The candidate will use computational and genomics approaches to identify targets of RNA binding proteins, and predict their impact on CRISPR-Cas regulation. Bioinformatics work will mainly consist of analysing data generated by new high-throughput sequencing technologies such as Tn-Seq (a.k.a. TraDIS) and RNA-seq, as well as comparative genomics.

The successful candidate will join a research group based at the University of Otago in Dunedin, New Zealand that has a broad range of interests including the application of bioinformatic methods to analyse comparative genomic, transcriptomic and proteomic datasets. In particular, we are interested in RNA biology and the consequences of prokaryotic genome variation.

You will join the Gardner Research Group http://www.ucbioinformatics.org which has recently joined the University of Otago. We will work in close collaboration with Associate Professor Peter Fineran. Our groups are diverse, and we collaborate widely, including with groups in the UK, Denmark, US, Sweden, Germany and Australia. We work towards the free and rapid dissemination of research discoveries.

Please email a CV with references and cover letter to Paul Gardner ([Email Address Removed]). If short-listed, we will request further details from you.

Funding Notes

Candidates should have an Honours or Master's degree in a biological or mathematical discipline such as biochemistry, genetics, molecular biology, maths, statistics, physics, computer science or equivalent, and a demonstrated interest in developing bioinformatic skills.

A PhD stipend of up to $28,000 per year for three years, plus fees will be provided by the Bio-Protection Research Centre.