Complex mixtures and fish responses: A new for legacy contaminated industrial sites.

A team of students, technicians, and post-doctoral fellows is being assembled to work with five toxicology professors, the local regulator, consulting company, and site owner, to develop innovative approaches to assess the human health and ecological risk associated with a complex operating site that contains a complex, unresolved mixture in groundwater and soil. The students and fellows will work at the University of Manitoba and the University of Saskatchewan Toxicology Group, one of the largest groups of its kind in North America (https://www.usask.ca/toxicology/). The selected candidate will be based at the University of Manitoba, with extensive lab work at the Toxicology Centre.

Through the use of effect-directed adverse outcome analysis, the selected student will use an aquatic whole animal model to confirm that the adverse outcomes predicted by cell lines are reflective of whole organim effects. Using standard fish models, we will identify and describe the dominant mode of toxic action occurring in groundwater. These experiments aim to confirm and validate the general and specific toxicological responses identified in vitro using microbial and human organ cell. Candidates should have a strong background in toxicology and/or fish biochemistry, as well as interest in biometrics and/or genomics. The project will involve the candidate working closely with three other PhD students who are working on cell lines and murine models of toxic action for this complex mixture. In addition, the project involves this candidate working closely with practicing risk assessors and a research associate well versed in analytical toxicology.

Applications must include a CV and cover letter outlining your background as it relates to the position. The names of at least two references must be provided. Applications will be reviewed as they are submitted.