About the Project
We invite applications for a PhD fellowship to join an internationally recognized research group at the iBV, University of Nice, France. Our team is interested in the molecular pathways that drive normal development and tissue renewal, as well as pathogenetic mechanisms leading to disease including cancer.
Adrenals are central hormone producing organs that control key parameters of body homeostasis. Organ maintenance is ensured through stem cell populations that reside in, or close to the adrenal capsule. Defects in stem cell renewal lead to rapid loss of organ function and are therefore life threatening. How adrenal stem cells are specified, how they are activated and how they differentiate is presently poorly understood. The successful candidate will work on the signalling pathways driving the differentiation of pluripotent stem cells into steroidogenic organs, analyse stem cell behavior and develop approaches for adrenal tissue engineering.
The ideal candidate will have achieved academic excellence, be highly motivated and have background in developmental/stem cell biology.
We can offer cutting-edge research projects, an international research environment and state-of-the-art equipment.
References
1. Vidal, V, Sacco S., Rocha AS, da Silva F, Dumontet T, Phuong Doan M, Shan J, Rak-Raszewska R, Bird T, Vainio, S, Martinez A and Schedl A (2016). The adrenal capsule is a signalling centre controlling cell renewal and zonation through Rspo3. Genes & Dev 30:1389-94
2. Bandiera R, Sacco S, Vidal VP, Chaboissier MC and Schedl A. (2015) Steroidogenic organ development and homeostasis: A WT1-centric view. Mol Cell Endocrinol. 15: 145-155. doi: 10.1016/j.mce.2015.01.009
3. Bandiera R, Vidal VPI, Ranc F, Clarkson M, Sahut-Barnola I, Tissier F, von Gise A, Bertherat J, Pu W, Hohenstein P, Martinez A and Schedl A. (2013) WT1 maintains adrenal-gonadal-primordium (AGP) identity and marks a novel population of AGP-like progenitors within the adult adrenal gland. Dev. Cell 27:5-18.
Continue with Facebook
