Defining mechanisms of immune dysfunction in the tumour microenvironment

Although tumours frequently contain immune infiltrates, our immune system is often unable to mount an effective anti-tumour response, and rather than clearing the lesion, immune populations may promote disease progression and metastasis. Despite these observations, the mechanisms employed by a growing tumour to avoid immune destruction remain unclear. However, recent evidence indicates that non-cancerous support cells within tumours, referred to as the stroma, may play a role. The Shields group aims to determine how and when the stroma is able to orchestrate immune dysfunction during tumour evolution, both in the local microenvironment and downstream lymph nodes. This project will take an innovative approach that integrates bioengineering principles, novel in vitro systems, state-of-the-art imaging techniques and in vivo tumour models. Our long-term goal is to translate this knowledge into targeted therapeutic platforms capable of restoring the anti-tumour response.
More information about the research undertaken in the Shields lab can be found here: www.mrc-cu.cam.ac.uk/research/Jacqui-Shields-folder

How to apply:
Applications will need to be made through the University Application Portal. Please visit: www.graduate.study.cam.ac.uk/courses/directory/cvcupdmsc/apply for further information about the programme and to access the Applicant Portal.

We have four separate projects at the Unit for which we are offering studentships (see related advertisements). You are allowed to apply for more than one project as part of the same online application. Whilst making your application please make it clear which project area(s) and principal investigator(s) you are interested in working with. Your online application will need to include:

• A CV, including full details of all University course grades to date.
• Contact details for two academic or professional referees.
• A personal statement outlining your interest in a specific project area, what you hope to achieve from a PhD, and your research experience to date.

The above information must be provided under relevant sections on the application portal.

Further notes on completing the ‘Research’ section on the application portal:

• In the ‘Research Title’ textbox, if you are applying for one project only, insert the project title. If you wish to apply for more than one project, insert ‘Cancer Research’.
• If you are applying for more than one project, in the ‘Research Summary’ textbox, please insert the project titles you wish to apply for.
• In the ‘Research Supervisor’ textbox, please insert the initials of the Supervisor(s) you wish to consider your application.
• Please also describe your research experience in the appropriate textbox.