Chromosome segregation in mitosis and meiosis

Interested individuals must follow Steps 1, 2 and 3 at this link on how to apply
http://www.ed.ac.uk/biology/prospective-students/postgraduate/pgr/how-to-apply


The laboratory investigates fundamental mechanisms of chromosome segregation (http://ohkura.bio.ed.ac.uk). Errors in chromosome segregation can be a cause or contributing factor in human illnesses, such as cancer or reproductive/birth defects. We are looking for an enthusiastic and talented student to join our team investigating the molecular regulation of spindle microtubules and chromosome organisation. This is an excellent opportunity to engage in exciting projects combining in vivo and in vitro approaches including live-imaging microscopy, genetics, mass-spectrometry and biochemistry. Potential projects include regulation of chromatin organisation by histone modifications and epigenetics, spatial and temporal control of kinesins and microtubule-associated proteins by phosphorylation and ubiquitination, kinetochore-microtubule interaction, and key differences between two modes of cell division, mitosis and meiosis. The studies will also have medical impacts on the understanding of infertility and aneuploidy in human reproduction and aneuploidy in cancer. The project will be tailor-made to suit the student’s interest and ability. During the course of PhD study, the student will use their initiative to run their own project independently through close interaction with colleagues and the supervisor.

Further Information

Information on the lab, research and publications can be found at http://ohkura.bio.ed.ac.uk. The laboratory is medium-sized and well funded by the Wellcome Trust and has an outstanding track record of conducting original research at the highest standard. It has successfully trained 14 PhD students, all of who are now working in science or medicine. The laboratory is in the Wellcome Centre for Cell Biology, which offers an exciting and interactive environment with outstanding scientific excellence.