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  Biochemical properties of ubiquitin E3-ligases


   Department of Biochemistry

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  Dr C Day  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

One PhD scholarship is available for a talented student interested in studying the biochemical properties of ubiquitin E3-ligases in Prof. Catherine Day’s laboratory in the Biochemistry Department, University of Otago, Dunedin, New Zealand.

My research group is interested in understanding the process of ubiquitin transfer. This post-translational modification influences many important cellular processes, yet regulation of ubiquitin attachment is poorly understood. Our research is largely aimed at understanding how RING E3 ligases are regulated and build ubiquitin chains of distinct linkages. In this project you will investigate the activity of a RING E3, undertake structural studies to identify critical interactions and elucidate how the assembly of chains is regulated.

The aim of our research is to understand E3 ligase function at the molecular level. The position offers opportunities to start a career in an area of increasing importance in biological research.

The University of Otago is the second most highly ranked university in New Zealand. The Biochemistry Department is well equipped for protein based research and houses state-of-the-art research platforms for mass spectrometry, crystallography and protein analysis (ITC, SPR, CD). My laboratory is interactive and well resourced.

The successful candidate will hold a BSc(Hons) or MSc in Molecular Biology, Biochemistry, or related discipline (GPA of 8.5 or greater), and be passionate about collaborative research.

Starting date is flexible but preferably Sept/Oct 2018.

Include in your application the following:
A copy of your CV. Your CV must show some background in protein purification and/or characterisation techniques. X-Ray crystallography experience would be a bonus.

A copy of your academic transcript

A pdf copy of your research dissertation or thesis (if available)

A written statement (300-500 words) outlining why this specific project is interesting to you. You must show evidence of some background knowledge of the topic.

Evidence of English language ability. Please note that the university has extremely strict requirements and there are no exceptions. All material provided will be used to assess english language capability.

English language requirements can be found at http://www.otago.ac.nz/study/entrance/otago001300.html#minp

The PhD position requires the applicant to be eligible for admission to the PhD programme at the University of Otago.

Please ensure you enter your email address correctly. We can not respond to applicants who enter incorrect addresses.

Funding Notes

Funding for this position is available via a University of Otago PhD Scholarship, and to qualify for this a GPA of 8.5 or greater is essential. (http://www.otago.ac.nz/study/scholarships/index.html).
Funding for the PhD scholarship is NZ$25,000 pa for three years. This scholarship is tax free and tuition fees are waived. You must study under a New Zealand student visa.