Ferritins as nano-cage bioreactors for synthetic biology applications (LEBRUNU18DTP2)

The cellular iron storage protein ferritin is composed of 24 subunits, arranged in a highly symmetric fashion to form an approximately spherical protein shell surrounding a hollow centre in which large amounts of iron can be stored as a ferric-oxy-hydroxide mineral. The ferritin protein shell can potentially accommodate a range of other molecules, and the aim of this studentship is to use synthetic biology approaches to develop bacterial and plant ferritins as microaerobic nano-cage bioreactors, through the encapsulation of proteins and peptides for biotechnological applications. Methodologies for peptide and protein encapsulation will be developed, with eventual targets including technologically relevant enzymes such as FeFe hydrogenase, which catalyses the reduction of protons to hydrogen gas. This reaction/enzyme is of great current interest because of its potential for large scale generation of clean energy. This multi-disciplinary project will be based in the Le Brun lab at UEA and the Balk lab at John Innes Centre and will involve protein biochemistry, spectroscopy and kinetics, offering excellent training potential for the appointed student.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 9th, 10th or 11th January 2018.
The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4 year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.
For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk

For more information on the supervisore for this project, please go here: https://www.uea.ac.uk/chemistry/people/profile/n-le-brun
Type of programme: PhD
Start date of project: 1st October 2018
Mode of study: Full time
Length of studentship: 4 years

Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.