Mechanisms of host cell subversion by the human pathogen Chlamydia trachomatis
Chlamydia trachomatis is the principal bacterial cause of sexually transmitted disease worldwide and ocular infections cause a form of blindness (trachoma) in Developing nations, designated as a neglected tropical disease. Chlamydiae replicate within eukaryotic host cells by building a specialised intracellular compartment termed an inclusion, which selectively engages host organelles but remains segregated from the endo-lysosomal system. Chlamydial ‘effector’ proteins, which are delivered into the host cell, direct the biogenesis of this remarkable pseudo-organelle but in most cases their functions remain poorly characterised. This project will apply a multidisciplinary approach spanning biochemistry, cell biology, bioimaging and emerging genetic techniques in Chlamydia to understand effector structure and function.
Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility**, with the possibility of additional funding in the fourth year depending on circumstances.**The studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about your fee status can be found at the following website:http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status . Applications from ineligible candidates will not be considered.
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