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Transcriptional regulators of neural development


About This PhD Project

Project Description

Basic Helix-loop-Helix transcription factors are master regulators of neural cell fate determination and differentiation. The activity of bHLH proteins is regulated by positively-acting and negatively-acting modulators that also have profound contributions to development and disease (Dev Cell 35:269-280 2015; Development 145:dev159426 2018). A PhD position is available to participate in the identification and characterization of novel regulators of bHLH gene function. The successful candidate will employ genetic, molecular genetic, and biochemical approaches to identify and characterize regulators of neurogenesis in the fruitfly Drosophila. The specific experiments may include biochemical, genetic, whole-genome sequencing and live imaging approaches.

An application to the PhD program in Biomedical Sciences at Albert Einstein College of Medicine will also be required. More details are available at http://www.einstein.yu.edu/education/phd/prospective-students/admissions.aspx.
The deadline for online submission of all materials is December 11, 2018. Applicants interested in the project should make contact with Prof. Baker directly as soon as possible and before 27 November 2018.

Albert Einstein College of Medicine is a premier, research-intensive medical school dedicated to innovative biomedical investigation and to the development of ethical and compassionate physicians and scientists. Inspired by the words of our namesake, we welcome students, faculty and staff from diverse backgrounds who strive to enhance human health in the community and beyond.
Graduate students will be eligible for university housing as well as stipend and tuition waiver.

The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

References

Wang, L.-H. and Baker, N.E. (2015) Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring Helix-Loop-Helix proteins. Develeopmental Cell 32:.191-202.
Wang, L.-H. and Baker, N.E. (2015) E-proteins and Id-proteins: helix-loop-helix partners in development and disease. Developmental Cell 35: 269-280.
Li, K., and Baker, N.E. (2018) Regulation of the Drosophila ID protein Extra Macrochaetae by proneural dimerization partners. Elife 7: e33967.
Baker, N.E., and Brown, N.L. (2018) All in the family: neuronal diversity and proneural bHLH genes. Development, 145: dev159426.

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