Disrupted cortical dynamics in autism spectrum disorders

There are over 7 billion people on this planet. Yet we are all unique. There is no one else like you. Our uniqueness stems from how our genes and experiences effect activity in the brain. Within your brain there are around 100 billion neurons that are engaged in complex electrical and chemical exchanges with one another. As the activity of these neurons change, so do you. We are interested in understanding how specific neurons and neuronal circuits regulate proper brain function and behaviour. Furthermore, the lab aims to investigate how disease leads to alterations in neuronal activity that leads to alterations in a person’s behaviour and actions.

During this PhD, your research will focus on Rett syndrome, a neurodevelopmental caused by mutations in Methyl-CpG-binding Protein 2 (MECP2). This disease is characterized by loss of hand skills, loss of spoken language, anxiety, and seizures. Your research will combine genetic, imaging, and advanced electrophysiology to reveal how the activity of single neurons and small populations of neurons are affected in Rett syndrome.

If you have questions or would like further information about the project, we encourage you to contact Dr Goffin before making your formal application.