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(MRC DTP) Mesenchymal stem cells preconditioning as therapeutic tool to promote recovery from stroke

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  • Full or part time
    Dr E Pinteaux
    Prof S Allan
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Stroke is a leading cause of death and disability worldwide but with limited therapies, thus new therapeutic strategies are urgently needed. Inflammation after stroke is associated with poor outcome and is thus an attractive therapeutic target. A key mediator of inflammation is the cytokine interleukin-1 (IL-1), and blocking IL-1 actions have shown promise for acute neuroprotection and recovery in preclinical stroke models, and is currently tested in stroke patients. A potential new approach in stroke therapy is the targeted application of human mesenchymal (stromal) stem cells (MSCs) that can exert potent anti-inflammatory, neuroprotective and regenerative actions. Our previous and current research project funded by the Stroke Association found that MSCs can be stimulated (‘primed’) by IL-1 and defined culture conditions (3D spheroid cultures) to exert potent anti-inflammatory effects in vitro. The aim of our proposal is to test the hypothesis that human MSCs can be primed by preconditioning treatments (IL-1, 3D cultures priming) to exert potent anti-inflammatory, neuroprotective and regenerative actions in clinically-relevant animal stroke models for their potential use in future stroke therapies. The primary anticipated outcome will be controlled therapeutic application of MSCs for stroke recovery.

https://www.research.manchester.ac.uk/portal/emmanuel.pinteaux.html
https://www.research.manchester.ac.uk/portal/stuart.allan.html
https://www.bmh.manchester.ac.uk/research/domains/neuroscience-mental-health/stroke/

Funding Notes

This project is to be funded under the MRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the MRC DTP website www.manchester.ac.uk/mrcdtpstudentships
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

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