Imaging force-dependent cytoskeletal dynamics in tumour cells

Actin-based cell membrane protrusions drive the growth and movement of cancer cells. However, the mechanisms initiating and controlling these processes are poorly understood. Tumour microenvironments have a complex and heterogeneous structure which is thought to act as an important cue in controlling cytoskeletal dynamics. However, analysis of cytoskeletal dynamics in 3D matrices is challenging as it requires advanced imaging.

This project will use advanced microscopy to enable analysis of the correlations between the cell matrix structure and the structure and dynamics of migrating cells. This will help to define the impact of force on cytoskeletal dynamics and tumour cell invasion in 3D environments, providing novel tools and insights into studying cancer cell behaviour within more physiologically relevant settings.

We are seeking students with a degree in the physical sciences or a biological background and a strong interest in imaging, exceptional analytical skills and a keen interest in developing biophysical techniques at the single molecule level. Students should have an interest in experimental work using advanced imaging and developing software tools to analyse and interpret their results.

Academic requirement: Minimum Upper Second (above 60%) BSc degree in a science subject (biology, biomedical sciences, chemistry, physics or engineering) or an MSc in relevant area.

Training: All students are regularly notified about skills development opportunities through a monthly Postgraduate Research Newsletter. Participation in the annual Postgraduate Research Symposium is compulsory for all students and provides an opportunity to improve science communication and presentation skills. All postgraduate students in the Randall present their research in seminars to the whole division as well as to their research groups. Opportunities are available for postgraduate students to present their work at national and international scientific meetings. Our postgraduate students also assist with teaching of undergraduates as demonstrators in practical classes or leading tutorials.

How to apply: Please apply online at https://apply.kcl.ac.uk/ following these steps: 1. Register a new account /login. 2. Open a new application 3. Under Choose a programme: a. Select - Research programme b. Keywords- enter Randall c. Select from the drop down ‘Randall Division of Cell and Molecular Biophysics MPhil/PhD (Full-time)’ (your application cannot be considered if submitted under the incorrect programme) d. Select October 2018 as the start date (NB. there is the option to start in July 2018 if preferred) 4. Complete your application

IMPORTANT: Please ensure that you quote reference number 18/RDCMB/S01 under ‘Research proposal’ and specify Dr Susan Cox as the supervisor. Please also quote the reference number 18/RDCMB/S01 in the funding section under question 4 in application form.

Interviews will be held around the end of April to early May.

Further details: It is highly recommended to informally approach Dr Susan Cox before the 6 April 2018. For administrative and application process enquiries please contact Helen Rudkin ([Email Address Removed]).