Role of galectin-1 in diabetes-induced vascular leakage.
Applications are invited for a three-year PhD fellowship at UCL Institute of Ophthalmology (IOO) under the supervision of Dr Patric Turowski and Prof Sobha Sivaprasad. The scheduled start date for this studentship is 1st January 2018. This project is aimed at characterising the role of galectin-1 during retinal vascular leakage. Retinal vascular leakage is a prevalent, sight-threatening condition that occurs as a consequence of diabetes. Diabetic retinal vascular leakage is predominantly driven by vascular endothelial growth factor (VEGF) but other independent mechanisms are also pathologically relevant. The successful candidate will be using cutting edge technology, in particular endothelial cell biology, physiology, immunohistochemistry and in vivo biology to study the contribution of galectin-1 to microvascular leakage and to VEGF signalling.
The IOO is one of the world’s leading centres of vision research. It is closely associated with Moorfields Eye Hospital (MEH) and the NIHR- funded BRC for Ophthalmology to ensure a strong focus on translational research and exceptional research and training opportunities. The IOO is part of the UCL School of Life and Medical Sciences (SLMS), a UK leader in medical and health research. The IOO is a major training centre for postgraduate students, with currently over 100 registered PhD/MD students.
Dr Turowski is an internationally–recognised expert in cell biology and signalling. To date he has supervised 10 PhD/MD and 7 MSc/MRes students. Key achievements have been published in IOVS, J Cell Sci, Mol Biol Cell, Dev Cell and PNAS.
Ideal person specification
• A good degree (2.1 or above; or equivalent EU/overseas degree) in a (vascular) biology/biomedical subject area, and in addition ideally a MSc in a related area
• Interested in cell biology and eye diseases as well as translational research
• Excellent experimental skills, preferably in vascular biology, and in molecular and cellular biology
• Good analytical/mathematical skills, preferably with some knowledge of statistical approaches
• Good communication skills - especially in written English
• Very strong work ethic, with the ability to think creatively and work within a team
Duties and Responsibilities
• In vitro and in vivo retinal endothelial cell biology
• Protein purification and characterisation
• Work in collaboration with other researchers
• Prepare progress reports for industrial partner
• Prepare presentations, including text and images, for delivery by self and others.
• Travel for collaboration and other meetings or conferences.
• Prepare manuscripts for submission to peer-reviewed journals.
• Contribute to the overall activities of the research team, department and be aware of UCL policies.
Please email Dr Patric Turowski for further information about the project ([Email Address Removed]).
Application is by CV and covering letter (including motivation for applying) emailed to [Email Address Removed]
This studentship is funded for 3 years by Bayer PLC. It will cover UK/EU UCL PhD tuition fees, laboratory cost and an annual salary stipend starting at £22,278.
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