Prof J O'Connor, Prof Ananya Choudhury, Dr Alan McWilliam
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
The advanced MR-Linac installed at The Christie offers potential huge advances in improving delivery of radiotherapy by improved image guidance and the potential for geometrical and biological adaptive radiotherapy. Initial work has concentrated on using anatomical MRI to guide adaptation. However, in this study we will evaluate if changes in functional MRI data (in particular imaging hypoxia) are feasible and have potential use in future clinical trials of adaptive radiotherapy.
In Manchester we have developed a new method of using MRI (termed oxygen- enhanced MRI; OE-MRI). This technique can measure and map tumour hypoxia. We have already shown that OE-MRI is robust and can detect changes in hypoxia seen in patients treated with radiotherapy. This PhD project will be a world-first, using this advanced MRI method in the context of optimising advanced radiotherapy delivery.
Specifically, OE-MRI methods will be applied to study bladder, cervical and prostate cancers. Signal temporal evolution and spatial precision will be determined and from this a protocol will be transferred to the MR-Linac system. Next, a study will be performed to evaluate the ability of OE-MRI to measure and map treatment effects induced by hypoxia-modification therapy and radiotherapy. Finally, gene signature and imaging data will be used to construct a preliminary model stratifying responders versus non-responders to therapy.
The project is inherently multidisciplinary. Supervision will be from world-leading experts in radiotherapy and cancer imaging, based within a thriving radiation research group. The appointed clinical fellow will have the opportunity to develop a mix of core skills and experience, and will be encouraged strongly to take ownership of a research area. It is ideal for developing experience in biomarker studies and clinical trials. Mentorship will be provided and this will be an ideal springboard towards developing an academic career.
For more information about this PhD scheme please visit http://www.crukcentre.manchester.ac.uk/Training/PhD-Training-Scheme
All applicants must:
• hold a minimum upper second class (or equivalent) undergraduate degree in relevant subject
• be post-registration clinicians and ideally have a specialist training post;
• have been resident and worked within the EEA (European Economic Area) for at least three years prior to application
Funding Notes
The Fellowships are usually tenable for three years, although in certain circumstances they may extend to four years duration. We will provide running expenses, an appropriate salary in line with the applicant’s current salary and grade and full coverage of University PhD fees.
Candidates whose nationality is outside the UK/EU will be awarded a contribution towards their fees equivalent to the amount awarded to home/EU students. Funding for the remaining fees will need to be identified in order to progress your application (the shortfall will be £15,879 per annum).
To apply please visit http://www.crukcentre.manchester.ac.uk/Training/PhD-Training-Scheme/Application-Process-and-Important-Dates