Functional Analysis of Eye Field Transcription Factors Using In Vitro Differentiation of Embryonic Stem Cells at University of Edinburgh on FindAPhD.com

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Prof D FitzPatrick No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

My lab uses in vitro differentiation of mouse embryonic stem cells to create the optic vesicle-like organoids in MRC HGU. We are interested in the gene regulatory networks controlling early eye development. We are using CRISPR Cas9 to insert protein tags into the endogenous loci of eye field transcription factors that are critical to these networks. These tags allow us to use live cell imaging, FACS sorting and immunoprecipitation (chromatin and protein-protein) to understand cell behaviour during differentiation project. We can also use them for timed degradation of the protein to observe the effect on the differentiation cascade,

This project is part of an MRC four-year PhD programme in Human Genetics, Genomics and Disease, at the MRC Human Genetics Unit, University of Edinburgh. See website for details of other projects.

Further information about the programme and details of how to apply please visit www.ed.ac.uk/mrc-human-genetics-unit/study-with-us

Funding Notes

Applicants should hold at least an upper second-class degree in a relevant subject and comply with English language requirements. For full funding students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.The studentship offers a stipend of £17,500 per annum.

Where will I study?

University of Edinburgh

One of the world''s top universities, consistently ranked in the world top 50 and placed 20th in the QS World University Rankings 2020. We provide a stimulating working, learning and teaching environment with access to excellent facilities and attract the world''s best, from Nobel Prize winning laureates to future explorers, pioneers and inventors.

Functional Analysis of Eye Field Transcription Factors Using In Vitro Differentiation of Embryonic Stem Cells

University of Edinburgh College of Medicine and Veterinary Medicine

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

Where will I study?

University of Edinburgh

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