Mechanistic Biology of FAN1 at University of Sheffield on FindAPhD.com

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Dr J A Grasby, Dr D Williams, Dr T Craggs No more applications being accepted

About the Project

Applications are invited for a BBSRC funded White Rose Doctoral Training Programme Studentship to study the recently discovered 5’-nuclease FAN1. The FAN1 protein plays vital roles in the repair of cross-linked DNA, but how FAN1 functions is currently unclear. This project will study the mechanism for FAN1 using a combination of steady and pre-steady state enzyme kinetics, oligonucleotide chemistry and biophysical techniques such as fluorescence (FRET).

The student will join a vibrant and world-leading research grouping within the Centre for Chemical Biology within the Krebs Institute for Mechanistic Biology. The four year BBSRC funded student will be able to access to a full range of career development and training opportunities via the DTP (https://www.whiterose-mechanisticbiology-dtp.ac.uk/).

Funding Notes

Candidates will have at least a 2.1 degree or equivalent in Chemistry, Biochemistry or a related discipline and will receive a tax free stipend (currently £14, 553 pa) for four years, funds for research costs and tuition fees. There are language requirements for international students.

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University of Sheffield

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Mechanistic Biology of FAN1

University of Sheffield Department of Chemistry