Luminescent lanthanide probes responsive to DNA targeting (MIBTP competition funded) at University of Birmingham on FindAPhD.com

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Prof Z Pikramenou, Dr N J Hodges No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

Birmingham United Kingdom

About the Project

Interaction of synthetic supramolecular systems with biologically active molecules has been of particular interest to address recognition features important to biomolecular function. Hairpin-shaped molecules have attracted particular interest for targeting specific DNA sequences. In this project we will develop self-assembled hairpin shaped lanthanide probes with DNA recognition units by controlling the hairpin structure with the choice of the ligand and the DNA recognition unit We will use specific targeting DNA sequences for disease detection (for example for detection of mutational events in cancer cells) and use the lanthanide signal to report the DNA binding event Specific cellular uptake will be assessed by confocal microscopy and photoxicity assessed using biochemical assays for viability, cellular ROS, DNA damage and apoptosis.

This project is a collaboration between Prof Zoe Pikramenou in the School of Chemistry and Dr Nik Hodges in the School of Biosciences providing multidisciplinary training. Expertise in Chemistry in the undergraduate degree is a requirement.

Interested applicants should contact Prof Pikramenou in the first instance [Email Address Removed] [Email Address Removed]

Funding Notes

This studentship is competition funded by the BBSRC MIBTP scheme:

The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.

References

Glover, P. B., Ashton, P. R., Childs, L. J., Rodger, A., Kercher, M., Williams, R. M., De Cola, L. & Pikramenou, Z. 2003, J. Amer. Chem. Soc. 125, 9918.

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Luminescent lanthanide probes responsive to DNA targeting (MIBTP competition funded)

University of Birmingham School of Chemistry