Regulation of NF-kB signalling by ribotoxic stress

The NF-kappaB pathway is a master regulator of the healthy response to infection and stress. It does this by regulating immune and inflammatory responses together with many cellular pathways such as apoptosis, proliferation and cell adhesion. Aberrant activation of NF-kappaB drives many age associated inflammatory diseases, such as arthritis and has been linked to premature ageing. This project addresses fundamental mechanisms that regulate NF-kappaB in both normal and pathological responses and builds upon data linking NF-kappaB function to ribotoxic stress through direct interaction with the 5S RNP. In addition to its ribosomal functions, an important cell-signalling role for components of the 5S RNP following nucleolar disruption by DNA damage and/or ribotoxic stress has emerged. The student on this project will investigate the nature, function and physiological significance of the interaction between NF-kappaB and the 5S RNP using state-of-the-art molecular cell biology techniques proteomics and CRISPR/Cas9 genome engineering.

For further information see the website: http://www.ncl.ac.uk/camb/

To apply:
Please complete the online application form and attach a full CV and covering letter - https://forms.ncl.ac.uk/view.php?id=553440. Informal enquiries may be made to [Email Address Removed]