Prof Salvador Macip
Applications accepted all year round
Self-Funded PhD Students Only
About the Project
Ageing is a biological process that affects all living creatures. Despite the scientific advances of the past decades, the mechanisms that lead to ageing in humans are not fully understood. Evidence suggests that accumulation of old (senescent) cells in tissues plays a critical role in the appearance of the symptoms associated with age. Indeed, recent experiments have showed that when old cells are eliminated from tissues, fitness and lifespan increases substantially.
Our work on senescence (cellular ageing) is aimed at better understanding why organisms age and providing the basis for new treatments that could be applied to slow down and improve ageing, as well as treating those diseases in which senescence has been shown to play a role (cancer, Alzheimer’s, obesity, fibrosis, etc.) . We have identified novel markers of senescence that can be used to detect senescent cells and we are using to design targeted therapies that can be tested in vitro and in vivo, in order to define novel anti-senescent strategies that could be applied clinically.
Funding Notes
Self-Funded applicants only
References
Althubiti M, Macip S. Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach. Methods Mol Biol. 2017;1534:147-153.
Althubiti M, Rada M, Samuel J, Escorsa JM, Najeeb H, Lee KG, Lam KP, Jones GD, Barlev NA, Macip S. BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Res. 2016 Sep 15;76(18):5405-14.
Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard C, Cain K and Macip S. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 2014 Nov 20;5:e1528.
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