About the Project
Cardiovascular diseases are the number one cause of morbidity and mortality in Western societies. Immune cells and their responses participate in all phases of atherosclerosis and repair processes after post-myocardial infarction.
We focus on the contribution of immune cells to cardiovascular biology, bridging immunology and cardiovascular pathology. There is a special interest in cell biology and the molecular signaling mechanisms driving atherogenic inflammation and myocardial infarction .
The PhD student will employ murine models of atherosclerosis and/or cardiac injury (myocardial infarction), combined with cutting edge tools in immune cell phenotyping and transcriptomics, as well as basic techniques commonly used in cellular and molecular biolog.
Funding Notes
Successful candidates should have studied Biology, Biochemistry, Pharmacy, Bioinfarmatics or a similar field of study, and have shown outstanding academic performance. Prerequisite is previous hands on experience with experimental mouse models and prior work in the field of inflammation, cardiovascular research or related areas. Suitable candidates should be highly motivated with an intrinsic interest in molecular and disease mechanisms.
References
Cochain C, Koch M, Chaudhari SM, Busch M, Pelisek J, Boon L, Zernecke A (2015) CD8+ T Cells Regulate Monopoiesis and Circulating Ly6C-high Monocyte Levels in Atherosclerosis in Mice. Circ Res. 117:244-53
Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A (2014) Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation. 129:598-606
Soehnlein O, Drechsler M, Döring Y, Lievens D, Hartwig H, Kemmerich K, Ortega-Gomez A, Mandl M, Vijayan S, Projahn D, Garlichs CD, Koenen RR, Hristov M, Lutgens E, Zernecke A*, Weber C*. (2013) Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med. 5(3):471-81. *equal contribution
Döring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, Zernecke A (2012) Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 32:1613-23
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