DiMeN Doctoral Training Partnership: Determining how post-transcriptional control of mRNA turnover and translation contributes towards age-associated joint diseases

Determining how post-transcriptional control of mRNA turnover and translation contributes towards age-associated joint diseases:

As our population ages it is increasingly important that we understand the mechanisms that underpin chronic diseases such as osteoarthritis. These diseases come at a significant cost at both individual and societal level and yet for many there are no disease modifying drugs available. This studentship will investigate how new therapeutic targets can be identified by examining how processes that influence joint tissue function are controlled at the post-transcriptional level. The successful candidate will determine how rates of mRNA turnover and protein translation affect genes that are known to control the integrity of the highly specialised extracellular matrix found in the articular cartilage of the joint. The project will use a variety of in vitro and in vivo approaches and will therefore provide training in a broad array of the molecular techniques necessary for studying both what happens to mRNAs after they are transcribed and how that contributes to overall gene regulation.

You will receive supervision from a team of academics who each bring key expertise that will support the project. Dr Simon Tew’s laboratory (University of Liverpool) has a long-standing interest in the role of post-transcriptional gene regulation in orthopaedic tissues. Professor George Bou-Gharios (University of Liverpool) is an expert on chronic diseases that affect extracellular matrices, with particular focus on the use of transgenic mouse models. Dr Julie Aspden (University of Leeds) heads a group focussed on understanding the molecular processes that control mRNA translation. In addition to training in a broad range of molecular laboratory techniques, the studentship will provide access to a diverse range of additional training opportunities aimed at supporting progression of the PhD and developing transferable skills.

The Institute of Ageing and Chronic Disease is fully committed to promoting gender equality in all activities. In recruitment, we emphasize the supportive nature of the working environment and the flexible family support that the University provides. The Institute holds a silver Athena SWAN award in recognition of on-going commitment to ensuring that the Athena SWAN principles are embedded in its activities and strategic initiatives.

Candidates should hold or be expected to obtain a First or Upper Second class Honours degree or a Master’s degree in a relevant Biological subject. If English is not your first language you must have IELTS 6.5 or equivalent, with no component below 5.5.